Package: decoupleR

in software package R

May 23, 2021

Overview

Many methods allow us to extract biological activities from omics data using information from prior knowledge resources, reducing the dimensionality for increased statistical power and better interpretability. Here, we present decoupleR, a Bioconductor package containing different statistical methods to extract these signatures within a unified framework. decoupleR allows the user to flexibly test any method with any resource. It incorporates methods that take into account the sign and weight of network interactions. decoupleR can be used with any omic, as long as its features can be linked to a biological process based on prior knowledge. For example, in transcriptomics gene sets regulated by a transcription factor, or in phospho-proteomics phosphosites that are targeted by a kinase.

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For more information about how this package has been used with real data, please check the following links:

Details
Posted on:
May 23, 2021
Length:
1 minute read, 149 words
Categories:
software package R
Tags:
software package R
See Also:
Iris dataset